Exploring and Exploiting Genetic Risk for Psychiatric Disorders

List of Contributors viiPreface xi1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1Gene Discovery 2 Delineating Additional Risk Factors 133 Data Collection: Next Steps in Psychiatric Genetics 394 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51Understanding Rare Variation 5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 696 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 1037 Experimental Model Systems for Rare and Common Variants 117Understanding Common Variation8 Common Alleles: Next Steps in the Study of Common Variants 1319 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 15510 From Common Variant to Function: State-of-the-Art Approaches 16711 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179Clinical Considerations 12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 20113 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 21914 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 23715 Psychiatric Genetic Counseling: Next Steps 24916 Concluding Summary 261Bibliography 267Subject Index 319Strungmann Forum Report Series 325